Main Page - Revision history

RobAsWikiUser at 11:35, 15 March 2026

2026-03-15T11:35:29Z

← Older revision		Revision as of 11:35, 15 March 2026
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	~~= Wikimaladie =~~		<strong>Advances biomedical science through integrating knowledge with quantitative models.</strong>

			This project aims to formalize and connect existing knowledge into predictive, multiscale modelling frameworks that can be evaluated against measurable data.



	== Mission ==		== Mission ==

RobAsWikiUser at 11:33, 15 March 2026

2026-03-15T11:33:46Z

← Older revision		Revision as of 11:33, 15 March 2026
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			= Wikimaladie =

	== Mission ==		== Mission ==
	Our goal is to integrate biological knowledge through computational modeling		Our goal is to integrate biological knowledge through computational modeling

RobAsWikiUser at 11:31, 15 March 2026

2026-03-15T11:31:16Z

← Older revision		Revision as of 11:31, 15 March 2026
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	* [[Carcinogenesis]]		* [[Carcinogenesis]]
	* (future diseases)		* (future diseases)

			== Getting started ==
			WikiMaladie uses MediaWiki, the same software that runs WikiPedia.
			Consult the [https://www.mediawiki.org/wiki/Special:MyLanguage/Help:Contents User's Guide] for information on using the wiki software.
			* [https://www.mediawiki.org/wiki/Special:MyLanguage/Manual:Configuration_settings Configuration settings list]
			* [https://www.mediawiki.org/wiki/Special:MyLanguage/Manual:FAQ MediaWiki FAQ]
			* [https://lists.wikimedia.org/postorius/lists/mediawiki-announce.lists.wikimedia.org/ MediaWiki release mailing list]
			* [https://www.mediawiki.org/wiki/Special:MyLanguage/Localisation#Translation_resources Localise MediaWiki for your language]
			* [https://www.mediawiki.org/wiki/Special:MyLanguage/Manual:Combating_spam Learn how to combat spam on your wiki]


			==Notes==
			<references />

RobAsWikiUser at 11:20, 15 March 2026

2026-03-15T11:20:39Z

Show changes

RobAsWikiUser at 13:26, 28 February 2026

2026-02-28T13:26:56Z

← Older revision		Revision as of 13:26, 28 February 2026
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	Behl, Christian. Alzheimer’s Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (p. 6). Springer International Publishing. Kindle Edition.		Behl, Christian. Alzheimer’s Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (p. 6). Springer International Publishing. Kindle Edition.
	</ref>		</ref>
	To find a cure for the disease, to find a disease changing medication, we must first understand the causal mechanisms at the origins of the disease, the aetiology. ~~We currently have~~ an ~~incredible wealth~~ of ~~detailed~~ knowledge ~~relevant to the disease~~. What~~'s needed~~ is ~~a means~~ to ~~integrate this~~ knowledge ~~to develop a more quantitative and rigorous science~~.		To find a cure for the disease, to find a disease changing medication, we must first understand the causal mechanisms at the origins of the disease, the aetiology.
			Over decades, an extensive body of experimental and clinical knowledge has been accumulated across molecular, cellular, and systems levels. What remains limited is the quantitative integration of these findings into mechanistically consistent, testable models.

			This project aims to formalize and connect existing knowledge into predictive, multiscale frameworks that can be evaluated against measurable data.


	== Alzheimer’s Disease Multiscale Modelling Project ==		== Alzheimer’s Disease Multiscale Modelling Project ==

RobAsWikiUser at 13:23, 28 February 2026

2026-02-28T13:23:24Z

← Older revision		Revision as of 13:23, 28 February 2026
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	Behl, Christian. Alzheimer’s Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (p. 6). Springer International Publishing. Kindle Edition.		Behl, Christian. Alzheimer’s Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (p. 6). Springer International Publishing. Kindle Edition.
	</ref>		</ref>
	To find a cure for the disease, to find a disease changing medication, we must first understand the causal mechanisms at the origins of the disease, the aetiology. We currently have an incredible wealth of detailed knowledge relevant to the disease. What's needed is a means to integrate this knowledge in develop a quantitative and rigorous science.		To find a cure for the disease, to find a disease changing medication, we must first understand the causal mechanisms at the origins of the disease, the aetiology. We currently have an incredible wealth of detailed knowledge relevant to the disease. What's needed is a means to integrate this knowledge to develop a more quantitative and rigorous science.
	== Alzheimer’s Disease Multiscale ~~Modeling~~ Project ==		== Alzheimer’s Disease Multiscale Modelling Project ==

	This initiative develops '''mechanistic, quantitative models''' of Alzheimer’s disease that connect molecular processes to brain-level observables.		This initiative develops '''mechanistic, quantitative models''' of Alzheimer’s disease that connect molecular processes to brain-level observables.

RobAsWikiUser at 13:11, 28 February 2026

2026-02-28T13:11:59Z

@@ Line 5: / Line 5: @@
 Behl, Christian. Alzheimer’s Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (p. 6). Springer International Publishing. Kindle Edition.
 </ref>
-To find a cure for the disease, to find a disease changing medication, we must first understand the causal mechanisms at the origins of the disease, the aetiology. We currently have many hypotheses about potentially relevant mechanisms in a causal chain, but it should be emphasized that we have few [[hypotheses about the primary origin]]. This should be contrasted with the situation for many other diseases. For sickle cell anemia we know the point mutation of this genetic disease. For the infectious disease AIDS, the primary cause is HIV, the human immunodeficiency virus. For various cancers, the origin is a set of mutations in a set of genes. In the Alzheimer's disease literature, this distinction between <i>primary cause</i> and relevant <i>causal mechanism in a causal chain</i> is lacking. Let's call hypotheses about the later [[non-primary mechanism hypotheses]] to be clear on this point.
+To find a cure for the disease, to find a disease changing medication, we must first understand the causal mechanisms at the origins of the disease, the aetiology. We currently have an incredible wealth of detailed knowledge relevant to the disease. What's needed is a means to integrate this knowledge in develop a quantitative and rigorous science.

RobAsWikiUser at 09:28, 9 January 2026

2026-01-09T09:28:41Z

← Older revision		Revision as of 09:28, 9 January 2026
Line 5:		Line 5:
	Behl, Christian. Alzheimer’s Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (p. 6). Springer International Publishing. Kindle Edition.		Behl, Christian. Alzheimer’s Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (p. 6). Springer International Publishing. Kindle Edition.
	</ref>		</ref>
	To find a cure for the disease, to find a disease changing medication, we must first understand the causal mechanisms at the origins of the disease, the aetiology. We currently have many hypotheses about potentially relevant mechanisms in a causal chain, but it should be emphasized that we have few hypotheses about the primary origin. This should be contrasted with the situation for many other diseases. For sickle cell anemia we know the point mutation of this genetic disease. For the infectious disease AIDS, the primary cause is HIV, the human immunodeficiency virus. For various cancers, the origin is a set of mutations in a set of genes. In the Alzheimer's disease literature, this distinction between <i>primary cause</i> and relevant <i>causal mechanism in a causal chain</i> is lacking. Let's call hypotheses about the later [[non-primary mechanism hypotheses]] to be clear on this point.		To find a cure for the disease, to find a disease changing medication, we must first understand the causal mechanisms at the origins of the disease, the aetiology. We currently have many hypotheses about potentially relevant mechanisms in a causal chain, but it should be emphasized that we have few [[hypotheses about the primary origin]]. This should be contrasted with the situation for many other diseases. For sickle cell anemia we know the point mutation of this genetic disease. For the infectious disease AIDS, the primary cause is HIV, the human immunodeficiency virus. For various cancers, the origin is a set of mutations in a set of genes. In the Alzheimer's disease literature, this distinction between <i>primary cause</i> and relevant <i>causal mechanism in a causal chain</i> is lacking. Let's call hypotheses about the later [[non-primary mechanism hypotheses]] to be clear on this point.

RobAsWikiUser at 09:25, 9 January 2026

2026-01-09T09:25:57Z

← Older revision		Revision as of 09:25, 9 January 2026
Line 5:		Line 5:
	Behl, Christian. Alzheimer’s Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (p. 6). Springer International Publishing. Kindle Edition.		Behl, Christian. Alzheimer’s Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (p. 6). Springer International Publishing. Kindle Edition.
	</ref>		</ref>
	To find a cure for the disease, to find a disease changing medication, we must first understand the causal mechanisms at the origins of the disease, the aetiology. We currently have many hypotheses about potentially relevant mechanisms in a causal chain, but it should be emphasized that we have ~~no hypothesis~~ about the primary origin. This should be contrasted with the situation for many other diseases. For sickle cell anemia we know the point mutation of this genetic disease. For the infectious disease AIDS, the primary cause is HIV, the human immunodeficiency virus. For various cancers, the origin is a set of mutations in a set of genes. In the Alzheimer's disease literature, this distinction between <i>primary cause</i> and relevant <i>causal mechanism in a causal chain</i> is lacking. Let's call hypotheses about the later [[non-primary mechanism hypotheses]] to be clear on this point.		To find a cure for the disease, to find a disease changing medication, we must first understand the causal mechanisms at the origins of the disease, the aetiology. We currently have many hypotheses about potentially relevant mechanisms in a causal chain, but it should be emphasized that we have few hypotheses about the primary origin. This should be contrasted with the situation for many other diseases. For sickle cell anemia we know the point mutation of this genetic disease. For the infectious disease AIDS, the primary cause is HIV, the human immunodeficiency virus. For various cancers, the origin is a set of mutations in a set of genes. In the Alzheimer's disease literature, this distinction between <i>primary cause</i> and relevant <i>causal mechanism in a causal chain</i> is lacking. Let's call hypotheses about the later [[non-primary mechanism hypotheses]] to be clear on this point.

RobAsWikiUser at 05:51, 6 December 2025

2025-12-06T05:51:04Z

← Older revision		Revision as of 05:51, 6 December 2025
Line 5:		Line 5:
	Behl, Christian. Alzheimer’s Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (p. 6). Springer International Publishing. Kindle Edition.		Behl, Christian. Alzheimer’s Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (p. 6). Springer International Publishing. Kindle Edition.
	</ref>		</ref>
	To find a cure for the disease, to find a disease changing medication, we must first understand the causal mechanisms at the origins of the disease, the aetiology. We currently have many hypotheses about potentially relevant mechanisms in a causal chain, but it should be emphasized that we have no hypothesis about the primary origin. Let's call the ~~former~~ [[non-primary mechanism hypotheses]] to be clear on this point.		To find a cure for the disease, to find a disease changing medication, we must first understand the causal mechanisms at the origins of the disease, the aetiology. We currently have many hypotheses about potentially relevant mechanisms in a causal chain, but it should be emphasized that we have no hypothesis about the primary origin. This should be contrasted with the situation for many other diseases. For sickle cell anemia we know the point mutation of this genetic disease. For the infectious disease AIDS, the primary cause is HIV, the human immunodeficiency virus. For various cancers, the origin is a set of mutations in a set of genes. In the Alzheimer's disease literature, this distinction between <i>primary cause</i> and relevant <i>causal mechanism in a causal chain</i> is lacking. Let's call hypotheses about the later [[non-primary mechanism hypotheses]] to be clear on this point.