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<strong>Let's work together to unravel the mystery of Alzheimer's Disease.</strong>

"A full comprehension of the causes of a deadly disease is the essential prerequisite to find a cure."
<ref>
Behl, Christian. Alzheimer’s Disease Research: What Has Guided Research So Far and Why It Is High Time for a Paradigm Shift (p. 6). Springer International Publishing. Kindle Edition. 
</ref>
To find a cure for the disease, to find a disease changing medication, we must first understand the causal mechanisms at the origins of the disease, the aetiology. We currently have many hypotheses about potentially relevant mechanisms in a causal chain, but it should be emphasized that we have no hypothesis about the primary origin. This should be contrasted with the situation for many other diseases. For sickle cell anemia we know the point mutation of this genetic disease. For the infectious disease AIDS, the primary cause is HIV, the human immunodeficiency virus. For various cancers, the origin is a set of mutations in a set of genes. In the Alzheimer's disease literature, this distinction between <i>primary cause</i> and relevant <i>causal mechanism in a causal chain</i> is lacking. Let's call hypotheses about the later [[non-primary mechanism hypotheses]] to be clear on this point.


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==Notes==
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