Editing Iowa Mutation Modeling Program (section)

==== 2.7 Immediate, testable predictions ====
Even with bold assumptions, the model yields falsifiable consequences:

* If CAA morphology implies <math>\alpha_{\mathrm{CAA}} \gg \alpha_{\mathrm{plaque}}</math>, oligomer load should scale with vascular/perivascular amyloid burden more strongly than with parenchymal plaque load.
* Regions with high vascular amyloid should exhibit disproportionately high markers of synaptic injury relative to plaque-centric AD, after controlling for total deposited mass.
* Interventions that reduce fibril surface availability (without necessarily reducing total mass) should reduce oligomer-associated toxicity signals more than expected from plaque mass reduction alone.

(These predictions should be linked later to specific observables: PET patterns, CSF markers, region-specific atrophy, vascular dysfunction readouts.)

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